Koshy G, Kawashima Y, Kiji M, et al

Materials and Methods: The subjects were 36 systemically healthy, non-smoking patients (34-66 years old). All patients presented moderate-to-advanced chronic periodontitis and had at least 5 teeth and 2 pocket sites with probing depth ≥ 5 mm in each quadrant and bone loss. Then, they were randomly distributed to 3 different groups. 1. conventional quadrant-wise mechanical debridement (QMD): supraand subgingival ultrasonic instrumentation + irrigant (distilled water) 2. full-mouth mechanical debridement with a water in a single visit (FMD + water): supraand subgingival ultrasonic instrumentation + irrigant (distilled water) 3. full-mouth mechanical debridement with povidone iodine in a single visit (FMD + povidone): supraand subgingival ultrasonic instrumentation +irrigant (1% povidone iodine) + chlorhexidine mouthwash twice a day + tongue brushing. In addition, all subjects were recalled every month for OHI and professional tooth cleaning.